Formulation and evaluation of controlled porosity osmotic pump for. Pdl and cd were prepared in various formulations physical mixtures and presumed. Water permeability through the films was determined based on the osmotic pump. A system that can deliver multidrug at a prolonged rate is very important for the treatment of various chronic diseases such as diabetes, asthma and heart disease. Osmotic pumps consist of an inner core containing drug and osmogens, coated with a semipermeable membrane. Controlled porosity osmotic pump tablet cpop system was designed to deliver nifedipine np and metoprolol mp in a controlled manner up to 12 h. A significant milestone in oral ndds is osmotic drug delivery system. Polyethylene glycol 200 was used as a plasticizer and poreforming agent and was incorporated into the cellulose acetate films at the varied concentrations. Osmotic pump, controlledporosity osmotic pump tablet. Also, the preparation of swellable controlled porosity osmotic pump tablet was facilitated by coating the core tablet with pore forming agent, thus eliminating the need for the more expensive laser drilling. Theeuwes et al, 1984 1985 controlled porous osmotic pump was developed from which drug is leached out from the coating, eliminating the need of complicated re. A at least one active agent surrounded by b a rate controlling water insoluble wall, having a fluid permeability of 6. The first cpop was designed to decrease the risk of extremely. A system that can deliver multidrug at a prolonged rate is very important for the treatment of.
The coating composition of cpop includes poreforming agent, which generates pores in contact with aqueous media. R1, phanidhar sastri1, ravikumar3, atin kalra1, pritam kanagale. Osmotic drug delivery systems, osmotic pump, semipermeable membrane. This video describes the inner parts of an alzet pump and how they operate to enable continuous delivery of experimental agents. In operation, the osmotic core acts by imbibing water from the surrounding medium via the abstract the aim of the present study was to design a controlled porosity osmotic pump tablet of atenolol. Research open access development and evaluation of. In this paper, various types of osmotically controlled drug delivery systems and the basic components of controlled porosity osmotic pump tablets have been discussed briefly. Enhancement of dissolution of glipizide from controlled. Formulation and evaluation of controlled porosity osmotic pump for oral delivery of ketorolac abstract background.
Nanosuspension coating as a technique to modulate the. Controlled porosity osmotic pump cpop it consists of tablet core having drug, osmogen and other additives, which is surrounded by semi permeable membrane with leachable pore forming agent. A controlled porosity osmotic pump cpop delivery system for sodium ferulate was prepared with cellulose acetate ca as semipermeable membrane, polyethyleneglycol 400 peg 400 as channeling. Then, controlled porosity osmotic pump cpop tablet of gliclazide was designed to deliver drug in a controlled manner up to 16 h.
After coming in contact with aqueous media, pore former dissolves and leaches out from the coating which creates microporous membrane around tablet. Controlled porosity osmotic pump for the delivery of. Optimization and development of swellable controlled. Controlled porosity osmotic pump contains watersoluble additives in the coating membrane, which in contact with aqueous environment dissolves and results in formation of micro porous membrane. Alzet pumps deliver by the process of osmotic displacement.
Formulation and optimization of controlled porosity osmotic pump tablets of zidovudine using mannitol as osmogen for the treatment of aids chinmayakeshari sahoo1, surepalli ram mohan rao2, muvvala sudhakar3 1ph. Osmoticcontrolled release oral delivery system wikipedia. The drug integrity and consistency is difficult to maintain. Osmotic drug delivery systems differ from diffusion based systems in that the delivery of the active agents is driven by an. Formulation and evaluation of oral controlled porosity. A controlled porosity osmotic pump system with biphasic release of theophylline the developed system was composed of a tabletintablet tnt core and a controlled porosity coating membrane osmotic agent. Formulation and optimization of controlled porosity.
Design and formulation of nanoporous controlled porosity. Design and formulation of nanoporous controlled porosity osmotic pumps cpops containing a poorly water soluble drug, glibenclamide leila azharshekoufeh b1, yousef javadzadeh1,2, mohammad barzegar jalali3, ali nokhodchi4 and javad shokri1 1drug applied research centre and faculty of pharmacy, tabriz university of medical sciences, tabriz, iran. The osmotic pressure is a colligative property of a solution in which the magnitude of. Pdf osmotic drug delivery system for zero order kinetic. To maintain an effective nacl concentration within the drug compartment over the release duration, nacl granules were coated with a microporous cellulose acetate butyrate 38120 film.
Chemists have investigated a leachable pegylated cellulose acetate complex as a promising approach for controlled porosity osmotic pump tablets of captopril. Enhancement of dissolution of glipizide from controlled porosity osmotic pump using a wicking agent and a solubilizing agent mahalaxmi. Pdf a novel controlled porosity osmotic pump system for. This results in the development of various controlled drug delivery system. Mechanism of action of controlled porosity osmotic pump. The present study aimed to prepare, optimize, and evaluate tapentadol hydrochloride controlled porosity osmotic pump cpop and to achieve the drug release at nearly zeroorder. Swellable, controlled porosity, osmotic pump tablet, taguchi orthogonal design, fraction. A controlled porosity osmotic pump cpop delivery system for sodium ferulate was prepared with cellulose acetate ca as semipermeable membrane, polyethyleneglycol 400. The developed system was composed of a tabletintablet tnt core and a controlled porosity coating membrane. When the dosage form combine the benefits of extended release with high. Advantages to deliver apis as liquid formulations and combine the benefits of extended. The instant invention is directed to an osmotic pump comprising.
Osmotic drug delivery systems international research. Development and evaluation of a oncedaily controlled. Cpop contains watersoluble additives in the coating membrane, which in contact with aqueous environment dissolves and results in formation of micro porous membrane. Osmotic pumps are most promising systems for controlled drug delivery. An overview of osmotic drug delivery system international journal. Full text pdf journal of applied pharmaceutical science. Hence osmotic drug delivery technique is most interesting and widely acceptable among all other techniques. Formulation aspects in development of controlled porosity. Osmotic system releases a drug at a predetermined zero order delivery rate based on osmosis. A a core which comprises a therapeutically effective amount of diltiazem lmalate and an effective buffering amount of sodium bitartrate surrounded by b a rate controlling water insoluble wall, having a fluid. These systems are used for both oral administration and implantation.
The objective of this work was to demonstrate that the incorporation of sulfobutylethercyclodextrin, sbe 7m cd, results in the complete and sustained release of a sparingly water. Drug release from the whole surface of device rather than from a single hole. Instead, we tried controlled porosity osmotic pump cpop system since preparation of cpop is simple. The osmoticcontrolled release oral delivery system oros is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semipermeable outer membrane and one or more small laser drilled holes in it. In other osmotic drug delivery systems size hole is critical 5. Effect of polyethylene glycol on cellulose acetate films. A controlled porosity osmotic pump system with biphasic release of theophylline was developed for the nocturnal therapy of asthma. Ebscohost serves thousands of libraries with premium essays, articles and other content including controlledporosity osmotic pump tabletsan overview. Osmotic drug delivery system as a part of modified release. Osmotic drug delivery devices are composed of an osmotically active drug core, which is surrounded by a rate controlling membrane. It is implantable pumps used for research in mice, rats. Special equipments are necessary for drilling orifices except for controlled porosity osmotic pumps. The elementary osmotic pump was also developed controlled porosity.
Controlled porosity osmotic pump the delivery orifice is formed by incorporation of a leachable watersoluble component in the coating material. Cpop tablets were developed where the delivery orifices were formed by the. Pdf formulation aspects in development of controlled. Solid dispersion sd of glz consisted of hydroxypropyl cellulose hpcssl as a polymeric solubilizer was manufactured by hot melt extrusion hme technology. A boxbehnken experimental design was applied to optimize. The development of oral controlled release system has been a challenge to formulation scientist due to their inability to restrain and localize the system at targeted areas of the gastrointestinal tract. Osmotically controlled oral drug delivery systems utilize osmotic pressure for controlled delivery of. Alza corporation of the usa was first to develop an oral osmotic pump and since today, they are the leaders in the field of osmotic pump drug delivery systems with a technology named oros. Keywords osmotic pump, controlled porosity osmotic pump tablet, semipermeable membrane, osmogent, leachable pore formers.
Development and evaluation of controlled porosity osmotic. Inert ingredients are necessary for osmotic tablet formulations. Formulation and evaluation of oral controlled porosity osmotic pump tablet of zaltoprofen, international journal for pharmaceutical research scholars. The aim of the current study was to design a controlled porosity osmotic pump cpopbased drug delivery system for controlled release of an nsaid agent, ketorolac tromethamine, which is expected to improve patient compliance due to reduced frequency. The cpop was prepared by the coating of polymers eudragit rspo and rlpo on a directly compressed core tablet. The instant invention is directed to an osmotic pump, for the controlled release of diltiazem lmalate to an environment of use, said pump comprising. A total of nine formulations were prepared by using the different polymers poly ethylene oxide, hpmc k15 m and ethyl cellulose in different ratios in each formulation were. A promising approach for controlled porosity osmotic pump tablets of captopril. As the tablet passes through the body, water is absorbed through the semipermeable membrane via osmosis, and the resulting osmotic. A controlled porosity osmotic pump system with biphasic. Controlledporosity osmotic pump tabletsan overview. View enhanced pdf access article on wiley online library html view download pdf for. Development and evaluation of controlled porosity osmotic pump for nifedipine and metoprolol combination rajagopal kumaravelrajan1, nallaperumal narayanan2 and venkatesan suba3 abstract background. The osmotic drug delivery systems suitable for oral administration typically consist of a compressed tablet core that is coated with a semipermeable membrane that has an oriice drilled on it by means of a laser beam or mechanical.
Zentner et al, 1991 1986 patent issue claiming a delivery system for controlled administration of drug to ruminants. Cpop tablet is a novel drug delivery system with eternally drug delivery rate as characteristic and controlled with the osmotic pressure difference between inside and outside of spm as drug delivery power. Controlled drug delivery systems offer spatial control over the drug release. A promising approach for controlled porosity osmotic pump. Formulation and evaluation of controlled porosity osmotic. So concentration of pore former in controlled porosity osmotic pump is important parameter in controlling the release rate. Controlled porosity solubility modulated osmotic pump.
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